Heat 3 Winner: Shruthi Srinivas, MD - Best of the Best in Pediatric Surgery 2024
Dr. Mina Yeina discussed lipid nanoparticle delivery of microRNA 148A and attenuation of intestinal inflammation during NEC
clinical0:04 ↗
Dr. Joseph Davidson presented on sexual function and fertility outcomes in Hirschsprung's disease patients
clinical0:20 ↗
Dr. Shruthi Srinivas presented outcomes from colonic pull-through for cloacal atrophy
clinical0:25 ↗
Dr. Kala presented on single-cell guided prenatal derivation of fetal organoids
clinical0:31 ↗
Dr. Zheng presented on clinical characteristics and MMP-7 levels for biliary atresia
clinical0:40 ↗
Dr. Shruthi Srinivas won Heat 3 with her presentation on outcomes from colonic pull-through for cloacal atrophy, differentiated by colon length, in a multi-institutional study
clinical1:15 ↗
The competition between the second and third presentations was very tight
opinion0:50 ↗
Necrotizing Enterocolitis
There are no clear predictive factors to identify which premature infants with early NEC will progress to require surgical intervention.
clinicalJose Zinter1:54 ↗
Rate of feeding advancement does not correlate with development of necrotizing enterocolitis.
Host summaryTodd Ponsky summarizing the discussion — not the host's own clinical position3:11 ↗
Probiotics have the most evidence for NEC prevention, supported by Cochrane database review.
Host summaryThe host summarizing the discussion — not the host's own clinical position3:35 ↗
Many U.S. institutions do not routinely use probiotics despite evidence, due to uncertainty about formulation and dosing.
clinicalJose Zinter4:19 ↗
Pneumoperitoneum is the only single factor that would prompt operation; otherwise a constellation of findings (pneumatosis, hemodynamic instability, fixed loop, worsening acidosis/ventilation) is required.
clinicalTodd Ponsky7:17 ↗
Focal abdominal wall erythema is one of the most sensitive indicators for underlying dead bowel in NEC.
clinical12:24 ↗
In a 600-g infant with pneumoperitoneum, transport to the OR increases risk of demise; bedside intervention (drainage or laparotomy) is preferred.
clinicalTim15:08 ↗
Approximately 30% of infants treated with peritoneal drainage alone do not require subsequent laparotomy.
Host summaryThe host summarizing the discussion — not the host's own clinical position16:21 ↗
The Moss New England Journal trial showed no difference in outcomes between peritoneal drainage and laparotomy in extremely low birth weight infants with NEC, but the study population was heterogeneous.
Host summaryTodd Ponsky summarizing the discussion — not the host's own clinical position17:44 ↗
Most panelists use 1 kg as the weight threshold above which they favor laparotomy over peritoneal drainage.
Host summaryTodd Ponsky summarizing the discussion — not the host's own clinical position19:06 ↗
Bilateral grade 4 intraventricular hemorrhage does not alter surgical decision-making unless the family requests comfort measures only.
opinion20:10 ↗
Primary anastomosis at initial NEC operation is rarely performed (8–10% of audience) due to inability to detect anastomotic leak in a sick neonate.
Host summaryTodd Ponsky summarizing the discussion — not the host's own clinical position21:55 ↗
Dr. Miguel Guelfand presented impressive results with primary anastomosis in NEC at a prior conference.
Host summaryTodd Ponsky summarizing the discussion — not the host's own clinical position22:01 ↗
The 'Shishka baby' technique involves placing a tube through multiple necrotic segments with a few stitches to hold them together, then bringing both ends out as stomas with proximal diversion.
clinical23:29 ↗
Stoma takedown is typically performed at 4–6 weeks postoperatively and 2 kg body weight, though recent data (Andrew Badillo) suggest earlier reversal may be safe.
Host summaryTodd Ponsky summarizing the discussion — not the host's own clinical position26:32 ↗
Bringing stomas out side-by-side in the incision (rather than separated) facilitates easier takedown without disturbing the entire abdominal cavity.
opinion27:00 ↗
In pan-intestinal necrosis, decompressing distended bowel may reduce ischemia and salvage additional segments.
clinical31:41 ↗
As of one year ago, no child with true NEC totalis (complete small bowel and colonic necrosis) has successfully survived intestinal transplant.
epidemiologicalJose Zinter33:54 ↗
The threshold for viable bowel length has dropped to approximately 20 cm of small bowel, with better outcomes if the colon is intact.
clinicalJose Zinter34:23 ↗
NEC: Update Course 2013
There are no clear predictive factors to identify which premature infants with early NEC will progress to require surgical intervention.
Host summaryThe host summarizing the discussion — not the host's own clinical position1:09 ↗
Probiotics are the only preventative strategy with Cochrane database support for reducing NEC incidence.
Host summaryThe host summarizing the discussion — not the host's own clinical position2:59 ↗
Rate of feeding and timing of feeding initiation do not impact NEC incidence.
Host summaryThe host summarizing the discussion — not the host's own clinical position3:14 ↗
Most U.S. institutions do not routinely use probiotics despite evidence, due to uncertainty about formulation and dosing.
epidemiological3:31 ↗