From
StayCurrentMD
Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus
hosted by Dr. Cecilia Gigena
Chapter 1 of 1 · Evidence & Research
PDA management trial
Non-inferiority trial of expectant management versus early ibuprofen for PDA in preterm infants
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What the experts said
A multi-center non-inferiority trial compared preterm infants treated with expectant management versus early ibuprofen for PDA
The trial enrolled 273 infants total
136 infants were treated with expectant management and 137 with early ibuprofen
In the expectant management group, 17.6% developed necrotizing enterocolitis
In the expectant management group, 33% developed bronchopulmonary dysplasia
In the expectant management group, the death rate was 14%
In the ibuprofen group, 15.4% developed necrotizing enterocolitis
In the ibuprofen group, 50% developed bronchopulmonary dysplasia
In the ibuprofen group, the death rate was 80%
Expectant management is non-inferior to early ibuprofen in preterm patients with PDA