StayCurrentMD · PAPS Best of the Best Winner
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Video·Published May 2022Older

PAPS Best of the Best Winner

With Dr. Sophie Carr & Dr. Rebecca Rentea

Chapter 1 of 3 · Evidence & Research

Event introduction

Introduction to Best of the Best Event and PAPS Finalist

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Intelligent Search· scoped to surgical site infections · not medical adviceSearch the whole library →
What the experts said15 expert statements · 4 host summaries
Surgical site infections are a costly yet modifiable source of morbidity, particularly within the neonatal population.
ClinicalSophie Carr
Equivalent data does not yet exist for the neonatal surgical population for CHG versus povidone antisepsis.
EpidemiologicalSophie Carr
The neonatal skin antisepsis protocol included lower limits of 34 weeks post-conception age and 1500 grams weight, limited to general surgery patients only.
ClinicalSophie Carr
The protocol used either 2% or 0.5% CHG based on age cutoffs.
ClinicalSophie Carr
Skin integrity was assessed using a validated tool called the neonatal skin condition score.
ClinicalSophie Carr
Implementation of the protocol occurred in February 2020.
ClinicalSophie Carr
A total of 50 patients were included in the protocol, none of which experienced adverse skin prep outcomes.
ClinicalSophie Carr
8% of patients on the CHG protocol developed SSIs within the 30-day post-op period compared to 14% in the matched retrospective povidone cohort.
EpidemiologicalSophie Carr
A comparison of SSI rates between the CHG versus povidone cohort revealed no significant difference.
EpidemiologicalSophie Carr
The majority of cases were class two clean-contaminated cases.
ClinicalSophie Carr
The protocol was largely modeled off the McGill protocol used in Quebec, Canada, which used a lower age cutoff of 28 weeks gestational age with a lower weight cutoff of 1,000 grams.
ClinicalSophie Carr
The project was conducted in conjunction with multiple SSI reduction initiatives including optimizing antibiotic prophylaxis, using adherent draping, and implementing a clean closure bundle for class two clean-contaminated cases.
ClinicalSophie Carr
The clean closure bundle included changing gloves prior to closure.
ClinicalSophie Carr
The decrease in SSI rate from 14% to 8% was not statistically significant.
EpidemiologicalSophie Carr
The protocol was used for all general surgery cases that did not have any open exposed mucosa and in which the patient was not allergic to CHG or IPA.
ClinicalSophie Carr
A growing body of evidence in adults suggests that chlorhexidine gluconate and isopropyl alcohol provide superior protection against SSIs than povidone.
Host summarySophie Carr summarizes what Dr. Rebecca Rentea said · not cited in answers
CHG antisepsis is commonly used for invasive non-surgical procedures in NICUs and for prevention of newborn nosocomial infections in developing countries.
Host summarySophie Carr summarizes what Dr. Rebecca Rentea said · not cited in answers
Current product labeling discourages CHG-IPA antisepsis in infants under two months of age due to limited safety data and concerns around adverse effects, particularly skin injuries.
Host summarySophie Carr summarizes what Dr. Rebecca Rentea said · not cited in answers
Less than 28 weeks gestational age is the primary population affected by adverse skin reactions in the literature.
Host summarySophie Carr summarizes what Dr. Rebecca Rentea said · not cited in answers