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Ewing Sarcoma
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Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
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Surgery remains the mainstay of treatment for primary chest wall tumors, composed of a demolitive phase and a reconstructive phase. — Chiara Oreglio, Dr. Chiara Oreglio - Best of the Best in Pediatric Surgery 2025 · 0:00
Dr. Chiara Oreglio - Best of the Best in Pediatric Surgery 2025
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Watch EUPSA's Dr. Chiara Oreglio's presentation on “Exploring the Role of Bioprosthesis for Chest Wall Reconstruction” at the 2025 Best of the Best in Pediatric Surgery event!
Moderators: Drs. Todd Ponsky, Dan von Allmen, and Meera Kotag
video9:18 · Mar 2025
Metastasectomy plays an important role as part of multimodal therapy for solitary pulmonary relapse in Ewing sarcoma — Sophia Schermerhorn, Current management of pulmonary relapse in Ewing sarcoma: A report from the Pediatric Surgical Oncology Research Collaborative · 0:57
Current management of pulmonary relapse in Ewing sarcoma: A report from the Pediatric Surgical Oncology Research Collaborative
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Audra J. Reiter, Lynn Huang, Jennifer H. Aldrink, Brian T. Craig, Andrew M. Davidoff, Lindsay J. Talbot, Jordan Coggins, Jasmine Smith, Katherine C. Bergus, Taleen A. MacArthur, Stephanie F. Polites, Roshni Dasgupta, Chloe Boehmer, Joseph
video1:14 · Dec 2025
Radiation decisions in young children involve nuanced discussions of toxicities including pulmonary function, cardiac exposure, wound healing, and chest wall development, individualized case by case — Luke Pater, Clinical & Research Update: Sarcoma w/ Drs. Roshni Dasgupta, Joseph Pressey, Arthur Meyer, Luke Pater · 1:01:48
Clinical & Research Update: Sarcoma w/ Drs. Roshni Dasgupta, Joseph Pressey, Arthur Meyer, Luke Pater
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This video presents a detailed clinical and research update on pediatric sarcomas from Cincinnati Children's, featuring a multidisciplinary team: with Drs. Roshni Dasgupta, Joseph Pressey, Arthur Meyers, & Luke Pater. It covers two complex
video1:06:24 · Sep 2026
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Current management of pulmonary relapse in Ewing sarcoma: A report from the Pediatric Surgical Oncology Research Collaborative
Writer et al. published a multi-center retrospective study in the Journal of Pediatric Surgery through PeaceSOC in 2024
clinicalSophia Schermerhorn0:05 ↗
PeaceSOC is a network of over 50 centers in North America that work together to improve outcomes in pediatric surgical oncology
clinicalSophia Schermerhorn0:07 ↗
The study examined patients less than 22 years old with initially localized Ewing sarcoma who developed first pulmonary relapse between 2007 and 2020 across 19 different centers
clinicalSophia Schermerhorn0:20 ↗
Among 33 patients studied, about 2/3 had relapse limited to the lungs
epidemiologicalSophia Schermerhorn0:32 ↗
Nearly half of patients with lung-limited relapse had just a solitary pulmonary nodule
epidemiologicalSophia Schermerhorn0:32 ↗
Patients with solitary pulmonary nodule were more likely to undergo metastasectomy and whole lung radiation
clinicalSophia Schermerhorn0:39 ↗
Patients with solitary pulmonary nodule had the highest overall three-year survival at 73%
epidemiologicalSophia Schermerhorn0:39 ↗
Three-year survival for patients with multiple nodules was 40%
epidemiologicalSophia Schermerhorn0:50 ↗
Three-year survival for patients with extrapulmonary disease was 23%
epidemiologicalSophia Schermerhorn0:50 ↗
Solitary pulmonary relapse may represent a biologically more favorable type of recurrence
opinionSophia Schermerhorn0:57 ↗
Solitary pulmonary relapse is more amenable to achieving meaningful local control
opinionSophia Schermerhorn0:57 ↗
Metastasectomy plays an important role as part of multimodal therapy for solitary pulmonary relapse in Ewing sarcoma
opinionSophia Schermerhorn0:57 ↗
Dr. Chiara Oreglio - Best of the Best in Pediatric Surgery 2025
Primary chest wall tumors are a rare entity in pediatric population with Ewing sarcoma being the most common one.
epidemiologicalChiara Oreglio0:00 ↗
Surgery remains the mainstay of treatment for primary chest wall tumors, composed of a demolitive phase and a reconstructive phase.
guidelineChiara Oreglio0:00 ↗
The material of choice for chest wall reconstruction must encompass features of both stiffness and malleability while being biologically compatible.
clinicalChiara Oreglio0:00 ↗
The reconstructive material must be able to physiologically integrate with tissues and cope with the ongoing growing process in pediatric patients.
clinicalChiara Oreglio0:00 ↗
The series includes the youngest patient affected by chest wall Ewing sarcoma reported in literature, an 18-month-old female.
epidemiologicalChiara Oreglio0:00 ↗
The institution used porcine acellular dermal collagen (Permacol) for chest wall reconstruction.
clinicalChiara Oreglio0:00 ↗
Three patients were treated: two males and one female (18 months old at diagnosis).
clinicalChiara Oreglio0:00 ↗
The surgical technique aims for 'drum-like tension'—tension strong enough to guarantee internal organ protection while accommodating chest wall growth.
clinicalChiara Oreglio0:00 ↗
A latissimus dorsi muscular flap is created, rotated, and fixated over the prosthesis with sparing of the thoracodorsal artery.
clinicalChiara Oreglio0:00 ↗
In all patients, at least three ribs were removed in accordance with oncological guidelines.
clinicalChiara Oreglio0:00 ↗
In two cases, there was diaphragmatic involvement that was removed and reconstructed with Permacol.
clinicalChiara Oreglio0:00 ↗
In one case with a large defect, two Stratos bars (rigid material) were used in addition to Permacol, instead of the usual four bars.
clinicalChiara Oreglio0:00 ↗
None of the patients reported any perioperative complications according to the Clavien classification.
clinicalChiara Oreglio0:00 ↗
R0 resection was reached in all cases.
clinicalChiara Oreglio0:00 ↗
All patients were able to restart chemotherapy within two months from surgery.
clinicalChiara Oreglio0:00 ↗
No limitations of movement are reported by any of the patients.
clinicalChiara Oreglio0:00 ↗
The youngest case shows no paradoxical chest wall movement at follow-up and is disease-free.
clinicalChiara Oreglio0:00 ↗
Permacol mesh presents good adaptability to the growing process with a reduced risk of rejection and infection.
opinionChiara Oreglio0:00 ↗
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