Pyloric Stenosis
Pyloric stenosis is hypertrophy and hyperplasia of the inner circular layer with associated mucosal hypertrophy
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Pyloric stenosis leads to gastric outlet obstruction in infants between 2 to 10 weeks of age
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Pyloric stenosis is more common in males
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There is increased risk for first born infants with a positive family history
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Patients with pyloric stenosis typically present with non-bilious vomiting, usually seen between 2 to 10 weeks of life
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Infants with pyloric stenosis are otherwise well appearing and hungry after vomiting
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Emesis in pyloric stenosis will progress until it is projectile
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Hyperbilirubinemia can occur in up to 14% of patients with pyloric stenosis due to downregulation of hepatic enzymes associated with starvation
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Bilious emesis should always be worked up to rule out intestinal malrotation with midgut volvulus
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Ultrasound is the gold standard for diagnosing pyloric stenosis
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Pyloric stenosis is diagnosed on ultrasound when pyloric muscle is 3 millimeters thick and 14 millimeters long or greater
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The classic electrolyte abnormality in pyloric stenosis is hypochloremic, hypokalemic, metabolic alkalosis
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Prolonged gastric outlet obstruction leads to persistent vomiting and loss of hydrochloric acid, which leads to hypochloremia and loss of protons leading to metabolic alkalosis
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The kidneys compensate for dehydration by increasing the activity of the sodium potassium pump to retain fluid, leading to urinary excretion of potassium to preserve sodium and water
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In later stages of pyloric stenosis, excretion of protons leads to paradoxical aciduria, which further worsens metabolic alkalosis
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In the US, pyloromyotomy is the standard of care for pyloric stenosis
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In some countries, atropine is used as a non-surgical option for pyloric stenosis, with a success rate of about 60 to 90%
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Cincinnati Children's follows a resuscitation protocol published by the Children's Mercy Group in Kansas City for pyloric stenosis
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If chloride is less than 85, give 3 boluses separated by an hour and then recheck labs
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If chloride is between 85 and 97, give two boluses
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If chloride is greater than 97, give 1 bolus
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If bicarbonate is greater than 40, give 3 boluses
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If bicarbonate is greater than or equal to 33, give 2 boluses
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Prior to going to the operating room, serum chloride must be corrected to greater than 100 and bicarbonate to less than 30
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The proximal edge of the pylorus can be easily identified as the antrum transitions to a thick pylorus
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The distal extent of the pyloromyotomy is generally to the crossing vein of Mayo or the white line, which marks the pyloroduodenal junction
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After the pyloromyotomy is completed, the submucosa should bulge into the myotomy site
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After adequate pyloromyotomy, each side of the pylorus should move independently
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Complications from pyloromyotomy include incomplete myotomy, mucosal perforation, aspiration, wound infection, and incisional hernias
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There is a slight increased risk of incomplete myotomy and perforation with a laparoscopic approach, but the overall low incidence of complications decreases the clinical significance of the differences between the two approaches
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