Pediatric Patients as a Source of Bias in Joseph Lister's Study of Antisepsis

Abstract

Joseph Lister's (1827–1912) use of carbolic acid to prevent wound infection in open fractures of the extremities (1865) provided a basic science rationale for the practice of surgery. His series of 11 patients included 4 children, aged 7 to 13. Children, today known to better survive a given injury when compared with adults, may have biased his results in favor of survival, and led him to conclude that his method of carbolic-soaked dressing changes prevented fatal wound sepsis. His success with antisepsis may have been less a testament to his application of germ theory to surgery than to the physiological resilience of his young patients.

Keywords

Hashtags

This article is published on an external journal. Click below to read the full text.