Quick Literature Updates Episode 8

The Pediatric Surgical Oncology Research Collaborative study reviewed 15 hospitals to examine how different institutions localize small pulmonary nodules in children.

Different institutions use wires, methylene blue dye, indocyanine green, micro coils, and technetium 99 in different combinations for pulmonary nodule localization.

There was no significant difference in the success of localization between all of the different pulmonary nodule localization techniques.

The only significant differences in pulmonary nodule localization were in which institution performed each technique, and in IR, OR, and anesthesia times.

In a single institution prospective study of around 40 pediatric patients who received Nuss bar repair for pectus excavatum with perioperative ERAS pain protocol, 92% of patients were discharged on post-operative day one.

Patients receiving Nuss repair with ERAS protocol had a reduction in the total number of morphine equivalent doses received without any difference in their pain scores at the time of discharge.

In a preclinical study of transamniotic stem cell therapy for intrauterine growth restriction, subjects were divided into four groups: untreated, saline only, MSC therapy, and MSC with primer.

Overall survival in the intrauterine growth restriction stem cell study was 75%.

Gross brain weight was significantly lower in IUGR subjects with no treatment or just saline, and significantly higher in those treated with MSC.

The primed MSC group revealed significantly lowered levels of TNF alpha and interleukin beta in their brain.

Primed MSC appears to reverse some of the central nervous system effects of intrauterine growth restriction.

The National Trauma Data Bank analysis included over 40,000 adolescent trauma victims who were intubated for more than 24 hours and survived until discharge.

At three days post-intubation, there was no difference in overall hospital length of stay for adolescent trauma victims receiving tracheostomy.

In adolescent trauma victims without TBI, tracheostomy before three days decreased ICU length of stay by about 16 days compared to later tracheostomy.

Similar trends of decreased ICU length of stay were seen for all children, regardless of TBI or non-TBI status, if they received a tracheostomy before 7 days of intubation.