Neuroblastoma PDQ®

In brief

Comprehensive NCI clinical reference for healthcare professionals managing neuroblastoma, the most common extracranial solid tumor in children. Covers evidence-based treatment protocols including risk-based stratification, multimodal therapy approaches with surgery, chemotherapy, radiation, and immunotherapy, plus prognostic factors and current clinical trial information.

• Neuroblastoma is the most common extracranial solid tumor in children, often presenting with abdominal mass or metastatic disease.
• Risk stratification uses age, stage, MYCN amplification, and histology to guide treatment intensity from observation to multimodal therapy.
• High-risk disease requires intensive chemotherapy, surgery, radiation, stem cell transplant, and immunotherapy for optimal outcomes.
• Infants with localized disease may have spontaneous regression; observation alone is appropriate for select low-risk patients.
• Long-term surveillance is essential due to risks of recurrence, secondary malignancies, and treatment-related late effects.

Written by the GCMD Library team from the guideline.