Increased Lymph Node Ratio Predicts Poor Survival in Pediatric Rhabdomyosarcoma
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Read the article on jpedsurg.org ↗Article · Nov 2019 · 1 min read
In brief
In brief
Retrospective analysis of 1,076 pediatric rhabdomyosarcoma patients demonstrates that lymph node ratio (LNR) >0.75 independently predicts worse disease-specific survival, with hazard ratio of 4.32. This novel prognostic marker, alongside alveolar histology and advanced stage, may help stratify risk and guide treatment intensity in pediatric RMS.
Written by the GCMD Library team from the article.
Background/Purpose
Lymph Node Ratio (LNR) is defined as the number of positive lymph nodes (pLN) divided by total lymph nodes (LN) examined. LNR correlates with recurrence and/or overall survival in many adult cancers but has not previously been described in pediatric oncologic disease. We hypothesized that LNR correlates with worse disease specific survival (DSS) in pediatric rhabdomyosarcoma (RMS).
Methods
Patients 0.75 (HR 4.32, P = 0.015), alveolar histology (HR 4.797, P