True or False: Absent Ganglion Cells in Fistula Tissue Confirm Hirschsprung's
Carousel1 min read·Published Oct 2026

True or False: Absent Ganglion Cells in Fistula Tissue Confirm Hirschsprung's

True or false quiz slide about ganglion cells in fistula tissue confirming Hirschsprung's disease diagnosis.
Slide debunking myth that fistula tissue lacks ganglion cells in Hirschsprung disease diagnosis.
Clinical decision guide for when to evaluate anorectal patients for Hirschsprung's disease.
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Carousel · Oct 2026 · 1 min read

In brief

In brief

Educational content examining the diagnostic value of ganglion cell absence in fistula tissue for confirming Hirschsprung disease. Addresses a common clinical question about pathologic confirmation in pediatric patients with suspected congenital aganglionic megacolon.

Written by the GCMD Library team from the carousel.

Slides

4 pages · click to turn to one

A clinical comparison chart displaying three treatment modalities in vertical columns with icons, percentage metrics, and outcome indicators. Each column uses distinct color coding and includes graphical representations of success rates, complication data, and patient ambulation outcomes. The layout emphasizes quantitative comparisons through bar charts and numerical callouts.

Hirschsprung disease. A social-media carousel made possible by Cincinnati Children's.
The text in the image

Pediatric Achalasia: Surgical Approach Comparison | Heller Myotomy: 78% Success | Esophageal Dilatation: 45% Success | POEM (Per-Oral Endoscopic Myotomy): 99% Success | 742 Cases Reviewed | Complication Rates | Training Requirements | Ambulation Outcomes: 71-83% with Cell Lines A&B vs 20% Control | In Utero Myelomeningocele Repair | Human Placental Mesenchymal Stromal Cells | Neuroprotection Study | Robotic vs Laparoscopic Surgery | Pediatric Surgical Techniques | Clinical Indications | Patient Selection Factors

The text on each slide
  1. Made possible by | Cincinnati Children's changing the outcome together | True vs False | Absent ganglion cells in fistula tissue confirm Hirschsprung's disease. | TRUE | FALSE | Make your call, then swipe. | Swipe right
  2. False | Fistula tissue isn't physiologic to begin with. | In one Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) single-center series: | 91% of fistula specimens had ganglion cells — absence alone doesn't confirm the diagnosis | Swipe right
  3. SO WHAT ACTUALLY PREDICTS IT? | ~4% had both ARM and Hirschsprung's — rare | 2 of 3 dual-diagnosis patients had Trisomy 21 | Aaron Garrison, MD | Pediatric Surgeon, Cincinnati Children's | Swipe right
  4. ✅ WHEN TO WORK THEM UP: | A complex anorectal patient who is: | → Not responding to laxatives or enemas | → And has a chromosomal anomaly | Both? Work them up for Hirschsprung's disease.
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