From
Dr. Amr Moursi
How Electrical Stimulation Changes Brain Circuits | Functional Neurosurgery Explained – Episode 4
With Dr. Amr Moursi
Part of
Parkinson's Disease 7 items
Chapter 1 of 1 · Fundamentals
Introduction
Introduction and Episode Overview
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Host summaries · secondary, not cited in answers
Educational content from recorded physician discussions — not medical advice. Talk to your (or your child's) care team about your situation.
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What the experts said
DBS is not a reversible lesion
High-frequency stimulation disrupts pathological beta oscillations
Pathological beta oscillations cause bradykinesia and rigidity
The hyperdirect pathway carries antidromic spikes back to motor cortex within milliseconds
The connectivity profile of the active contact matters more than its coordinates
Dorsolateral STN and ventromedial STN produce completely different clinical outcomes
Chronic stimulation induces synaptic plasticity and neurochemical change
Dystonia takes months to respond to DBS
DBS mechanism operates through three layers: fast electrical effects, network remodelling, and plasticity
In DBS programming, you are programming axons not grey matter