Association between image-defined risk factors and neuroblastoma outcomes
jpedsurg.org shows its articles on its own site.
Read the article on jpedsurg.org ↗Article · Mar 2019 · 1 min read
In brief
In brief
Retrospective study examining how image-defined risk factors (IDRFs) correlate with surgical and oncologic outcomes in 106 pediatric neuroblastoma cases. IDRF-positive tumors at diagnosis associated with MYCN amplification and poor differentiation; IDRF positivity before resection correlated with higher stage, risk classification, and tumor volume.
Written by the GCMD Library team from the article.
Background
The current neuroblastoma (NBL) staging system employs image-defined risk factors (IDRFs) to assess numerous anatomic features, but the impact of IDRFs on surgical and oncologic outcomes is unclear.
Methods
The Vanderbilt Cancer Registry identified children treated for NBL from 2002 to 2017. Tumor volume (TV) and IDRFs were measured radiographically at diagnosis and before resection. Perioperative and oncologic outcomes were evaluated.
Results
At diagnosis of 106 NBL, 61% were IDRF positive. MYCN-amplified and undifferentiated NBL had more IDRFs than nonamplified and more differentiated tumors (p = 0.001 and p = 0.01). Of 86 NBLs resected, 43% were IDRF positive, which associated with higher stage, risk, and TV (each p