And I think, uh, nowadays it's CSI procedure is still the first line treatment for bilireatresia, but as we can see, there's some patients, um, could not achieve their jaundice clearance and their um they couldn't live long for uh with their native liver.
Jingying Jiang, MD - Best of the Best in Pediatric Surgery 2024
▶Ep 20 · 0:42
quoteBreatresia is a severe liver disease characterized by fibro inflammatory destruction of bi ducts.↗
▶Ep 20 · 0:42
clinicalBiliary atresia is a severe liver disease characterized by fibro-inflammatory destruction of bile ducts.↗
▶Ep 20 · 0:42
quoteBreatresia is a severe liver disease characterized by fibro inflammatory destruction of bi ducts.↗
▶Ep 20 · 0:42
clinicalBiliary atresia is a severe liver disease characterized by fibro-inflammatory destruction of bile ducts.↗
▶Ep 20 · 0:48
clinicalMMP-7 can help precisely discriminate BA from other cholestatic diseases at a cutoff value of around 20 ng/mL.↗
▶Ep 20 · 0:48
quoteRecently, it has been reported that MMP 7 can help precisely discriminate BA from other cholecystic diseases at a cutoff value of around 20.↗
▶Ep 20 · 1:00
quoteHowever, there were Still 5 to 10% of patients with force negative MMP7 whose characteristics and prognosis remain unknown.↗
▶Ep 20 · 1:00
epidemiological5 to 10% of BA patients have false negative MMP-7 levels.↗
▶Ep 20 · 1:24
clinicalThe study reviewed 329 BA patients who underwent Kasai procedure from 2020 to 2022.↗
▶Ep 20 · 1:24
clinicalThe study reviewed 329 BA patients who underwent Kasai procedure from 2020 to 2022.↗
▶Ep 20 · 1:34
clinicalPatients were divided into low MMP-7 and high MMP-7 groups based on preoperative MMP-7 levels of 20-25 ng/mL.↗
▶Ep 20 · 1:34
clinicalPatients were divided into low MMP-7 and high MMP-7 groups based on preoperative MMP-7 levels of 20-25 ng/mL.↗
▶Ep 20 · 2:03
clinicalThe median MMP-7 level for low MMP-7 group was 20.19 ng/mL compared with 66.55 ng/mL for the high MMP-7 group.↗
▶Ep 20 · 2:03
clinicalThe median MMP-7 level for low MMP-7 group was 20.19 ng/mL compared with 66.55 ng/mL for the high MMP-7 group.↗
▶Ep 20 · 2:16
clinicalPreoperative gamma-GT and direct bilirubin in the low MMP-7 group were significantly lower than those in the high MMP-7 group.↗
▶Ep 20 · 2:16
clinicalPreoperative gamma-GT and direct bilirubin in the low MMP-7 group were significantly lower than those in the high MMP-7 group.↗
▶Ep 20 · 2:26
clinicalFibrosis stages were significantly different between the low and high MMP-7 groups.↗
▶Ep 20 · 2:26
clinicalFibrosis stages were significantly different between the low and high MMP-7 groups.↗
▶Ep 20 · 2:34
clinicalThree-month jaundice clearance rate was 46.91% for the high MMP-7 group and 29.73% for the low MMP-7 group.↗
▶Ep 20 · 2:34
clinicalThree-month jaundice clearance rate was 46.91% for the high MMP-7 group and 29.73% for the low MMP-7 group.↗
▶Ep 20 · 2:50
clinicalSix-month jaundice clearance rate was 54.51% for the high MMP-7 group and 32.14% for the low MMP-7 group.↗
▶Ep 20 · 2:50
clinicalSix-month jaundice clearance rate was 54.51% for the high MMP-7 group and 32.14% for the low MMP-7 group.↗
▶Ep 20 · 3:03
clinicalA total of 90 patients in the low MMP-7 group and 112 patients in the high MMP-7 group died or underwent liver transplantation by the latest follow-up.↗
▶Ep 20 · 3:03
clinicalA total of 90 patients in the low MMP-7 group and 112 patients in the high MMP-7 group died or underwent liver transplantation by the latest follow-up.↗
▶Ep 20 · 3:16
clinicalOne-year native liver survival rate was 29.63% for the low MMP-7 group and 53.02% for the high MMP-7 group.↗
▶Ep 20 · 3:16
clinicalOne-year native liver survival rate was 29.63% for the low MMP-7 group and 53.02% for the high MMP-7 group.↗
▶Ep 20 · 3:29
quoteSo taken together, around 10% of VA patients have low 7 MMP 7 levels.↗
▶Ep 20 · 3:29
quoteSo taken together, around 10% of VA patients have low 7 MMP 7 levels.↗
▶Ep 20 · 3:29
epidemiologicalAround 10% of BA patients have low MMP-7 levels.↗
▶Ep 20 · 3:29
epidemiologicalAround 10% of BA patients have low MMP-7 levels.↗
▶Ep 20 · 3:41
quoteOur previous study suggested. Low gamma GT levels correlated with more severe liver injury and poor outcomes.↗
▶Ep 20 · 3:41
clinicalLow gamma-GT levels correlated with more severe liver injury and poor outcomes in a previous study.↗
▶Ep 20 · 3:50
clinicalBA patients in the low MMP-7 group had a lower jaundice clearance rate and native liver survival rate.↗
▶Ep 20 · 3:50
clinicalBA patients in the low MMP-7 group had a lower jaundice clearance rate and native liver survival rate.↗
▶Ep 20 · 3:59
quoteSo more subjects and a long-term follow-up are warranted to determine whether this could be listed as a new clinical subtype of BA.↗
▶Ep 20 · 3:59
quoteSo more subjects and a long-term follow-up are warranted to determine whether this could be listed as a new clinical subtype of BA.↗
▶Ep 20 · 4:11
quoteOne of our limitations in this study was the period of follow-up maybe not long enough for some patients, ranging from 3 months to 3 years, and some patients lost follow up within 3 months and were excluded from final analysis which may Introduceed buyers to the results.↗
▶Ep 20 · 4:11
quoteOne of our limitations in this study was the period of follow-up maybe not long enough for some patients, ranging from 3 months to 3 years, and some patients lost follow up within 3 months and were excluded from final analysis which may Introduceed buyers to the results.↗
▶Ep 20 · 4:11
clinicalSome patients lost to follow-up within 3 months were excluded from final analysis.↗
▶Ep 20 · 4:11
clinicalThe follow-up period ranged from 3 months to 3 years.↗
▶Ep 20 · 4:11
clinicalThe follow-up period ranged from 3 months to 3 years.↗
▶Ep 20 · 4:11
clinicalSome patients lost to follow-up within 3 months were excluded from final analysis.↗
▶Ep 20 · 4:30
clinicalPatients did not take MMP-7 measurements post-Kasai procedure in this study.↗
▶Ep 20 · 4:30
clinicalPatients did not take MMP-7 measurements post-Kasai procedure in this study.↗
▶Ep 20 · 4:30
quoteFinally, the patients did not take MMP 7 measurements post Kasa procedure.↗
▶Ep 20 · 4:30
quoteFinally, the patients did not take MMP 7 measurements post Kasa procedure.↗
▶Ep 20 · 4:36
quoteHowever, the dynamic analysis of MMP 7 levels postoperatively will be meaningful in further understanding the mechanism.↗
▶Ep 20 · 4:36
quoteHowever, the dynamic analysis of MMP 7 levels postoperatively will be meaningful in further understanding the mechanism.↗
▶Ep 20 · 5:26
clinicalMMP-7 measurement is based on ELISA method.↗
▶Ep 20 · 5:26
clinicalMMP-7 measurement is based on ELISA method.↗
▶Ep 20 · 5:26
quoteSo, the MMP 7 measurement is based on the 7, and, uh, it is based on the method of Eliza.↗
▶Ep 20 · 5:26
quoteSo, the MMP 7 measurement is based on the 7, and, uh, it is based on the method of Eliza.↗
▶Ep 20 · 5:36
clinicalMMP-7 testing is not very popular in every hospital in China, just in some institutions.↗
▶Ep 20 · 5:36
clinicalMMP-7 testing is not very popular in every hospital in China, just in some institutions.↗
▶Ep 20 · 5:44
clinicalMMP-7 testing costs about 1000 RMB per patient in China.↗
▶Ep 20 · 5:44
clinicalMMP-7 testing costs about 1000 RMB per patient in China.↗
▶Ep 20 · 5:44
quoteSo it's cost about uh I think 1000 RMB for each patient, uh, each measurement.↗
▶Ep 20 · 5:44
quoteSo it's cost about uh I think 1000 RMB for each patient, uh, each measurement.↗
▶Ep 20 · 6:14
quoteAnd I think, uh, nowadays it's CSI procedure is still the first line treatment for bilireatresia, but as we can see, there's some patients, um, could not achieve their jaundice clearance and their um they couldn't live long for uh with their native liver.↗
▶Ep 20 · 6:14
guidelineKasai procedure is still the first line treatment for biliary atresia.↗
▶Ep 20 · 6:14
clinicalSome BA patients could not achieve jaundice clearance and could not live long with their native liver after Kasai.↗
▶Ep 20 · 6:14
quoteAnd I think, uh, nowadays it's CSI procedure is still the first line treatment for bilireatresia, but as we can see, there's some patients, um, could not achieve their jaundice clearance and their um they couldn't live long for uh with their native liver.↗
▶Ep 20 · 6:14
guidelineKasai procedure is still the first line treatment for biliary atresia.↗
▶Ep 20 · 6:14
clinicalSome BA patients could not achieve jaundice clearance and could not live long with their native liver after Kasai.↗
▶Ep 20 · 6:34
opinionIf the mechanism of MMP-7 in biliary atresia becomes clear, patients with low MMP-7 might go directly for liver transplantation in the future.↗
▶Ep 20 · 6:34
quoteSo someday if we are definitely uh clear about their mechanism of MMP 7 in bilireresia, maybe someday, the patients with low MMP 7 can go directly for liver transplantation.↗
▶Ep 20 · 6:34
quoteSo someday if we are definitely uh clear about their mechanism of MMP 7 in bilireresia, maybe someday, the patients with low MMP 7 can go directly for liver transplantation.↗
▶Ep 20 · 6:34
opinionIf the mechanism of MMP-7 in biliary atresia becomes clear, patients with low MMP-7 might go directly for liver transplantation in the future.↗
Summaries Zhang gave as host
· 6 summaries
Recaps of other experts' statements, not Zhang's own clinical position.
Summaries Zhang gave as host · Biliary Atresia6 summaries
Jingying Jiang, MD - Best of the Best in Pediatric Surgery 2024
▶Ep 20 · 0:48
host summaryZhang Jing summarizing a resource: MMP-7 can help precisely discriminate BA from other cholestatic diseases at a cutoff value of around 20 ng/mL.↗
▶Ep 20 · 0:48
host summaryZhang Jing summarizing a resource: Recently, it has been reported that MMP 7 can help precisely discriminate BA from other cholecystic diseases at a cutoff value of around 20.↗
▶Ep 20 · 1:00
host summaryZhang Jing summarizing a resource: However, there were Still 5 to 10% of patients with force negative MMP7 whose characteristics and prognosis remain unknown.↗
▶Ep 20 · 1:00
host summaryZhang Jing summarizing a resource: 5 to 10% of BA patients have false negative MMP-7 levels.↗
▶Ep 20 · 3:41
host summaryZhang Jing summarizing a resource: Our previous study suggested. Low gamma GT levels correlated with more severe liver injury and poor outcomes.↗
▶Ep 20 · 3:41
host summaryZhang Jing summarizing a resource: Low gamma-GT levels correlated with more severe liver injury and poor outcomes in a previous study.↗
