Yuichiro Miyake

22 statements · 1 topic

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▶ Ep 28 · 0:21
CDH patients present with a hole in the diaphragm and abnormal lung development resulting in lung hypoplasia and persistent pulmonary hypertension
clinical · Congenital Diaphragmatic Hernia
▶ Ep 28 · 0:21
Fetoscopic endoluminal tracheal occlusion (FETO) is currently performed to increase survival rate of CDH babies
clinical · Congenital Diaphragmatic Hernia

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Yuichiro's statements about Congenital Diaphragmatic Hernia 22 statements

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Yuichiro Miyake, MD - Best of the Best in Pediatric Surgery 2024

▶ Ep 28 · 0:21
clinical A microinjector was designed based on a microinsemination device to investigate combination of FETO with drug administration ↗
▶ Ep 28 · 0:21
quote Our research represent a significant step forward in the quest to improve outcomes for CDH babies. ↗
▶ Ep 28 · 0:21
epidemiological The incidence of CDH is 1 in 2000 to 5000 live births ↗
▶ Ep 28 · 0:21
epidemiological About 150 CDH babies are born every day in the world ↗
▶ Ep 28 · 0:21
epidemiological About 50 CDH babies die every day ↗
▶ Ep 28 · 0:21
clinical Fetoscopic endoluminal tracheal occlusion (FETO) is currently performed to increase survival rate of CDH babies ↗
▶ Ep 28 · 0:21
clinical In a randomized controlled trial, FETO improved the survival rate for severe CDH from 15% to 40% ↗
▶ Ep 28 · 0:21
clinical Chitosan nanoparticles possess the ability to encapsulate various therapeutic substances ↗
▶ Ep 28 · 0:21
opinion Combining FETO with nanoparticle-based drug delivery could potentially lead to better outcomes for CDH babies ↗
▶ Ep 28 · 0:21
clinical Rat fetuses were removed on embryonic day 18 for the lung explant model ↗
▶ Ep 28 · 0:21
clinical Nanoparticles were injected into the trachea and the trachea was tied with surgical suture to replicate the FETO model ↗
▶ Ep 28 · 0:21
clinical An IgG antibody selected to target pulmonary tissue was used to functionalize the nanoparticles ↗
▶ Ep 28 · 0:21
clinical IgG nanoparticles exhibited superior uptake into the lungs compared to bare nanoparticles ↗
▶ Ep 28 · 0:21
clinical The relative number of nanoparticles to DAPI was about 2.5-fold higher in the IgG nanoparticles group compared to bare nanoparticles ↗
▶ Ep 28 · 0:21
clinical Active caspase-3 protein abundance was not significantly different among control, bare nanoparticles, and IgG nanoparticles groups ↗
▶ Ep 28 · 0:21
clinical IL-6 protein abundance was not significantly different among control, bare nanoparticles, and IgG nanoparticles groups ↗
▶ Ep 28 · 0:21
quote We hypothesize combining fetal with nanoparticles-based drug delivery could potentially lead to even better outcomes for CH babies. ↗
▶ Ep 28 · 0:21
clinical CDH patients present with a hole in the diaphragm and abnormal lung development resulting in lung hypoplasia and persistent pulmonary hypertension ↗
▶ Ep 28 · 0:21
quote Can you imagine a future where congenital anomalies can be treated during fetal development with nanoparticles? ↗
▶ Ep 28 · 0:21
quote So what can we do to improve the outcome of sedate babies? This should be a challenge for all pediatric surgeons. ↗
▶ Ep 28 · 5:44
clinical Lungs were dissected from rat pups, nanoparticles injected, trachea tied, and cultured for 2-3 days before analysis ↗
▶ Ep 28 · 6:21
opinion The next step involves encapsulating therapeutic agents in chitosan nanoparticles and testing whether they improve lung development in the explant model ↗