Infants with intestinal failure have compromised intestinal function, putting them at increased risk of malabsorption and electrolyte and fluid deficits.
At BC Women's Hospital, urine sodium is used as a non-invasive marker to estimate total body sodium in infants with intestinal failure, with a value above 30 suggesting sodium sufficiency.
The urine sodium to urine creatinine ratio offers a non-invasive measure which accounts for variable urine flow and has shown to be strongly correlated with fractional excretion of sodium.
Fractional excretion of sodium is the optimum measure of total body sodium but is inconvenient in the pediatric population as it requires a paired urine and blood sample.
CAPS - The use of urine sodium to creatinine ratio as a marker of total body sodium in infants with intestinal failure - Sara Choi
▶Ep 5 · 0:36
clinicalInfants with intestinal failure have compromised intestinal function, putting them at increased risk of malabsorption and electrolyte and fluid deficits.↗
▶Ep 5 · 0:36
quoteInfants with intestinal failure have compromised intestinal function, putting them at increased risk of malabsorption and electrolyte and fluid deficits.↗
▶Ep 5 · 0:45
quoteSodium depletion can go unrecognized, resulting in poor growth, refractory to increased caloric intake.↗
▶Ep 5 · 0:45
clinicalSodium depletion can go unrecognized, resulting in poor growth refractory to increased caloric intake.↗
▶Ep 5 · 1:00
clinicalSodium supplementation has been shown to be associated with weight gain and overall growth in infants with intestinal failure.↗
▶Ep 5 · 1:04
clinicalSerum sodium does not reflect total sodium stores.↗
▶Ep 5 · 1:04
quoteIt is difficult to determine how much sodium should be supplemented as serum sodium does not reflect total sodium stores.↗
▶Ep 5 · 1:14
clinicalFractional excretion of sodium is the optimum measure of total body sodium but is inconvenient in the pediatric population as it requires a paired urine and blood sample.↗
▶Ep 5 · 1:29
clinicalAt BC Women's Hospital, urine sodium is used as a non-invasive marker to estimate total body sodium in infants with intestinal failure, with a value above 30 suggesting sodium sufficiency.↗
▶Ep 5 · 1:44
clinicalUrine sodium doesn't account for volume status, therefore can result in oversupplementation or under supplementation with sodium.↗
▶Ep 5 · 1:57
quoteThe urine sodium to urine creatinine ratio offers a non-invasive measure, which accounts for variable urine flow and has shown to be strongly correlated with FINA, thus potentially acting as a more accurate marker of sodium status.↗
▶Ep 5 · 1:57
clinicalThe urine sodium to urine creatinine ratio offers a non-invasive measure which accounts for variable urine flow and has shown to be strongly correlated with fractional excretion of sodium.↗
▶Ep 5 · 2:13
clinicalThe use of the urine sodium to creatinine ratio has not yet been validated in the intestinal failure population.↗
▶Ep 5 · 3:18
epidemiologicalIn the study cohort of 22 infants, median gestational age was 31 weeks, median birth weight was 1.9 kg, and median age of enrollment was 8 days.↗
▶Ep 5 · 3:30
epidemiologicalGastroschisis was the most common etiology of intestinal failure in the study cohort.↗
▶Ep 5 · 3:41
clinicalThere was no significant correlation between either urine sodium or the ratio with daily weight gain when evaluating the entire data set.↗
▶Ep 5 · 4:04
clinicalThe ratio was more strongly associated with sodium intake when compared to urine sodium alone.↗
▶Ep 5 · 4:18
clinicalUrine sodium values above 29 and ratio values above 35 best predicted adequate weight gain.↗
▶Ep 5 · 4:28
clinicalThe urine sodium threshold of 29 is similar to previous studies, as it is generally accepted that urine sodium values above 30 is suggestive of sodium sufficiency.↗
▶Ep 5 · 4:41
clinicalIn the majority of urine sodium and ratio values, both markers were concordant, meaning that if urine sodium value met the threshold, then the ratio also met the threshold.↗
▶Ep 5 · 4:54
clinicalIn 19% of the time, the urine sodium and ratio values were discordant.↗
Sarah's statements about Intestinal Failure21 statements
CAPS - The use of urine sodium to creatinine ratio as a marker of total body sodium in infants with intestinal failure - Sara Choi
▶Ep 14 · 0:36
clinicalInfants with intestinal failure have compromised intestinal function, putting them at increased risk of malabsorption and electrolyte and fluid deficits.↗
▶Ep 14 · 0:36
quoteInfants with intestinal failure have compromised intestinal function, putting them at increased risk of malabsorption and electrolyte and fluid deficits.↗
▶Ep 14 · 0:45
clinicalSodium depletion can go unrecognized, resulting in poor growth refractory to increased caloric intake.↗
▶Ep 14 · 0:45
quoteSodium depletion can go unrecognized, resulting in poor growth, refractory to increased caloric intake.↗
▶Ep 14 · 1:00
clinicalSodium supplementation has been shown to be associated with weight gain and overall growth in infants with intestinal failure.↗
▶Ep 14 · 1:04
quoteIt is difficult to determine how much sodium should be supplemented as serum sodium does not reflect total sodium stores.↗
▶Ep 14 · 1:04
clinicalSerum sodium does not reflect total sodium stores.↗
▶Ep 14 · 1:14
clinicalFractional excretion of sodium is the optimum measure of total body sodium but is inconvenient in the pediatric population as it requires a paired urine and blood sample.↗
▶Ep 14 · 1:29
clinicalAt BC Women's Hospital, urine sodium is used as a non-invasive marker to estimate total body sodium in infants with intestinal failure, with a value above 30 suggesting sodium sufficiency.↗
▶Ep 14 · 1:44
clinicalUrine sodium doesn't account for volume status, therefore can result in oversupplementation or under supplementation with sodium.↗
▶Ep 14 · 1:57
quoteThe urine sodium to urine creatinine ratio offers a non-invasive measure, which accounts for variable urine flow and has shown to be strongly correlated with FINA, thus potentially acting as a more accurate marker of sodium status.↗
▶Ep 14 · 1:57
clinicalThe urine sodium to urine creatinine ratio offers a non-invasive measure which accounts for variable urine flow and has shown to be strongly correlated with fractional excretion of sodium.↗
▶Ep 14 · 2:13
clinicalThe use of the urine sodium to creatinine ratio has not yet been validated in the intestinal failure population.↗
▶Ep 14 · 3:18
epidemiologicalIn the study cohort of 22 infants, median gestational age was 31 weeks, median birth weight was 1.9 kg, and median age of enrollment was 8 days.↗
▶Ep 14 · 3:30
epidemiologicalGastroschisis was the most common etiology of intestinal failure in the study cohort.↗
▶Ep 14 · 3:41
clinicalThere was no significant correlation between either urine sodium or the ratio with daily weight gain when evaluating the entire data set.↗
▶Ep 14 · 4:04
clinicalThe ratio was more strongly associated with sodium intake when compared to urine sodium alone.↗
▶Ep 14 · 4:18
clinicalUrine sodium values above 29 and ratio values above 35 best predicted adequate weight gain.↗
▶Ep 14 · 4:28
clinicalThe urine sodium threshold of 29 is similar to previous studies, as it is generally accepted that urine sodium values above 30 is suggestive of sodium sufficiency.↗
▶Ep 14 · 4:41
clinicalIn the majority of urine sodium and ratio values, both markers were concordant, meaning that if urine sodium value met the threshold, then the ratio also met the threshold.↗
▶Ep 14 · 4:54
clinicalIn 19% of the time, the urine sodium and ratio values were discordant.↗
Sarah's statements about Intestinal Rehab21 statements
CAPS - The use of urine sodium to creatinine ratio as a marker of total body sodium in infants with intestinal failure - Sara Choi
▶Ep 58 · 0:36
quoteInfants with intestinal failure have compromised intestinal function, putting them at increased risk of malabsorption and electrolyte and fluid deficits.↗
▶Ep 58 · 0:36
clinicalInfants with intestinal failure have compromised intestinal function, putting them at increased risk of malabsorption and electrolyte and fluid deficits.↗
▶Ep 58 · 0:45
quoteSodium depletion can go unrecognized, resulting in poor growth, refractory to increased caloric intake.↗
▶Ep 58 · 0:45
clinicalSodium depletion can go unrecognized, resulting in poor growth refractory to increased caloric intake.↗
▶Ep 58 · 1:00
clinicalSodium supplementation has been shown to be associated with weight gain and overall growth in infants with intestinal failure.↗
▶Ep 58 · 1:04
quoteIt is difficult to determine how much sodium should be supplemented as serum sodium does not reflect total sodium stores.↗
▶Ep 58 · 1:04
clinicalSerum sodium does not reflect total sodium stores.↗
▶Ep 58 · 1:14
clinicalFractional excretion of sodium is the optimum measure of total body sodium but is inconvenient in the pediatric population as it requires a paired urine and blood sample.↗
▶Ep 58 · 1:29
clinicalAt BC Women's Hospital, urine sodium is used as a non-invasive marker to estimate total body sodium in infants with intestinal failure, with a value above 30 suggesting sodium sufficiency.↗
▶Ep 58 · 1:44
clinicalUrine sodium doesn't account for volume status, therefore can result in oversupplementation or under supplementation with sodium.↗
▶Ep 58 · 1:57
quoteThe urine sodium to urine creatinine ratio offers a non-invasive measure, which accounts for variable urine flow and has shown to be strongly correlated with FINA, thus potentially acting as a more accurate marker of sodium status.↗
▶Ep 58 · 1:57
clinicalThe urine sodium to urine creatinine ratio offers a non-invasive measure which accounts for variable urine flow and has shown to be strongly correlated with fractional excretion of sodium.↗
▶Ep 58 · 2:13
clinicalThe use of the urine sodium to creatinine ratio has not yet been validated in the intestinal failure population.↗
▶Ep 58 · 3:18
epidemiologicalIn the study cohort of 22 infants, median gestational age was 31 weeks, median birth weight was 1.9 kg, and median age of enrollment was 8 days.↗
▶Ep 58 · 3:30
epidemiologicalGastroschisis was the most common etiology of intestinal failure in the study cohort.↗
▶Ep 58 · 3:41
clinicalThere was no significant correlation between either urine sodium or the ratio with daily weight gain when evaluating the entire data set.↗
▶Ep 58 · 4:04
clinicalThe ratio was more strongly associated with sodium intake when compared to urine sodium alone.↗
▶Ep 58 · 4:18
clinicalUrine sodium values above 29 and ratio values above 35 best predicted adequate weight gain.↗
▶Ep 58 · 4:28
clinicalThe urine sodium threshold of 29 is similar to previous studies, as it is generally accepted that urine sodium values above 30 is suggestive of sodium sufficiency.↗
▶Ep 58 · 4:41
clinicalIn the majority of urine sodium and ratio values, both markers were concordant, meaning that if urine sodium value met the threshold, then the ratio also met the threshold.↗
▶Ep 58 · 4:54
clinicalIn 19% of the time, the urine sodium and ratio values were discordant.↗
