Ryan Morgan

49 statements · 1 topic · summaries given as host listed separately

Colorectal / ARM & Hirschsprung · guest expert

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▶ Ep 127 · 4:57
When isolated in a germ-free mouse model, the high fat diet associated microbiome significantly increased the rate of post-operative tumor development.
quote · Colorectal / ARM & Hirschsprung
▶ Ep 127 · 6:30
High-fat diet mice showed derangement of microbiome with overabundance of Alobaum and bloom of pathogenic bacteria such as Proteus, E. coli, and Shigella on postoperative day 7.
clinical · Colorectal / ARM & Hirschsprung

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Ryan's statements about Colorectal / ARM & Hirschsprung 49 statements

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Best of the Best Gen Surg - Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence - Dr. Morgan

▶ Ep 127 · 0:45
clinical Traditional paradigms suggest recurrences are due to either incomplete resection or occult metastases left behind at the time of surgery. ↗
▶ Ep 127 · 0:45
epidemiological Colorectal cancer is a leading cause of cancer deaths, particularly in cases of recurrence. ↗
▶ Ep 127 · 0:45
epidemiological Colorectal cancer is a leading cause of cancer deaths, particularly in cases of recurrence. ↗
▶ Ep 127 · 0:58
clinical Exfoliated cancer cells in the lumen of the bowel may be a source of recurrence. ↗
▶ Ep 127 · 1:04
clinical In the 1980s, UMLB showed that exfoliated cancer cells are present and viable at the time of surgery. ↗
▶ Ep 127 · 1:09
clinical Experimental cells could cross a watertight anastomosis in a mouse model. ↗
▶ Ep 127 · 1:14
clinical Rectal washout decreases rates of local recurrence after rectal cancer resection. ↗
▶ Ep 127 · 1:39
clinical When the primary colorectal tumor is resected, exfoliated cells remain behind within the lumen of the bowel and interact with the anastomotic microenvironment. ↗
▶ Ep 127 · 1:39
clinical When the primary colorectal tumor is resected, exfoliated cells remain behind within the lumen of the bowel and interact with the anastomotic microenvironment. ↗
▶ Ep 127 · 1:48
clinical Multiple factors can influence the anastomotic environment, including diet, the microbiome, and the tumor genetic background. ↗
▶ Ep 127 · 1:48
clinical Multiple factors can influence the anastomotic environment, including diet, the microbiome, and the tumor genetic background. ↗
▶ Ep 127 · 1:55
quote We propose that the interaction of these factors in the healing anastomosis promotes the migration of these cells to cause both local and distant recurrences. ↗
▶ Ep 127 · 1:55
quote We propose that the interaction of these factors in the healing anastomosis promotes the migration of these cells to cause both local and distant recurrences. ↗
▶ Ep 127 · 2:04
quote our hypothesis is that a high fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells. ↗
▶ Ep 127 · 2:04
clinical A high-fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells. ↗
▶ Ep 127 · 2:04
clinical A high-fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells. ↗
▶ Ep 127 · 2:04
quote our hypothesis is that a high fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells. ↗
▶ Ep 127 · 2:15
clinical AKPT and KPN organoid cell lines demonstrate a wide range of metastatic potential in animal models. ↗
▶ Ep 127 · 3:35
clinical AKPT mice showed significantly higher rate of tumor formation with a high-fat diet compared to mice given a chow diet by 56 days. ↗
▶ Ep 127 · 3:35
clinical AKPT mice showed significantly higher rate of tumor formation with a high-fat diet compared to mice given a chow diet by 56 days. ↗
▶ Ep 127 · 3:46
clinical KPN mice showed no significant difference in tumor formation based on diet, with an opposite trend towards higher rates in the chow diet. ↗
▶ Ep 127 · 3:46
clinical KPN mice showed no significant difference in tumor formation based on diet, with an opposite trend towards higher rates in the chow diet. ↗
▶ Ep 127 · 4:08
clinical AKPT mice given a high-fat diet had significantly decreased survival compared to those on a chow diet. ↗
▶ Ep 127 · 4:08
clinical AKPT mice given a high-fat diet had significantly decreased survival compared to those on a chow diet. ↗
▶ Ep 127 · 4:14
clinical KPN mice did not show any similar survival trend, suggesting that response to diet was at least in part based on the organoid genetic background. ↗
▶ Ep 127 · 4:14
clinical KPN mice did not show any similar survival trend, suggesting that response to diet was at least in part based on the organoid genetic background. ↗
▶ Ep 127 · 4:57
quote When isolated in a germ-free mouse model, the high fat diet associated microbiome significantly increased the rate of post-operative tumor development. ↗
▶ Ep 127 · 4:57
quote When isolated in a germ-free mouse model, the high fat diet associated microbiome significantly increased the rate of post-operative tumor development. ↗
▶ Ep 127 · 4:57
clinical In germ-free mice, the high-fat diet-associated microbiome significantly increased the rate of postoperative tumor development (40% vs 10-12% in control and chow FMT groups). ↗
▶ Ep 127 · 4:57
clinical In germ-free mice, the high-fat diet-associated microbiome significantly increased the rate of postoperative tumor development (40% vs 10-12% in control and chow FMT groups). ↗
▶ Ep 127 · 5:50
clinical Two-week diet reversal period was insufficient; mice in the reversal group continued to have poor survival and high tumor rates similar to the high-fat diet group. ↗
▶ Ep 127 · 5:50
clinical Two-week diet reversal period was insufficient; mice in the reversal group continued to have poor survival and high tumor rates similar to the high-fat diet group. ↗
▶ Ep 127 · 6:01
clinical Six-week diet reversal resulted in significantly increased survival and tumor rate similar to chow-fed mice, suggesting the response to diet and its reversal was time dependent. ↗
▶ Ep 127 · 6:01
clinical Six-week diet reversal resulted in significantly increased survival and tumor rate similar to chow-fed mice, suggesting the response to diet and its reversal was time dependent. ↗
▶ Ep 127 · 6:30
clinical High-fat diet mice showed derangement of microbiome with overabundance of Alobaum and bloom of pathogenic bacteria such as Proteus, E. coli, and Shigella on postoperative day 7. ↗
▶ Ep 127 · 6:30
clinical High-fat diet mice showed derangement of microbiome with overabundance of Alobaum and bloom of pathogenic bacteria such as Proteus, E. coli, and Shigella on postoperative day 7. ↗
▶ Ep 127 · 6:45
quote the reversal group very closely mirrors the composition of the child group, both in its baseline composition and in its response to surgery, suggesting that the reversal in phenotype we saw may be due to changes in the microbiome. ↗
▶ Ep 127 · 6:45
clinical The diet reversal group microbiome composition closely mirrored the chow group both in baseline composition and in response to surgery. ↗
▶ Ep 127 · 6:45
clinical The diet reversal group microbiome composition closely mirrored the chow group both in baseline composition and in response to surgery. ↗
▶ Ep 127 · 6:45
quote the reversal group very closely mirrors the composition of the child group, both in its baseline composition and in its response to surgery, suggesting that the reversal in phenotype we saw may be due to changes in the microbiome. ↗
▶ Ep 127 · 7:23
opinion Preoperative diet manipulation reduces tumor formation, suggesting a clinically relevant role for diet rehabilitation in colorectal cancer treatment. ↗
▶ Ep 127 · 7:23
quote with diet reversal experiments, we're able to show that preoperative diet manipulation reduces tumor formation by suggesting that there may be a clinically relevant role for diet rehabilitation and colorectal cancer treatment. ↗
▶ Ep 127 · 7:23
quote with diet reversal experiments, we're able to show that preoperative diet manipulation reduces tumor formation by suggesting that there may be a clinically relevant role for diet rehabilitation and colorectal cancer treatment. ↗
▶ Ep 127 · 7:23
opinion Preoperative diet manipulation reduces tumor formation, suggesting a clinically relevant role for diet rehabilitation in colorectal cancer treatment. ↗
▶ Ep 127 · 9:23
clinical Combined mechanical and antibiotic bowel preparation preoperatively decreases rates of colorectal cancer recurrence. ↗
▶ Ep 127 · 11:05
clinical Preliminary in vitro data shows AKPT cells have more proliferative response to secondary bile acids (like deoxycholic acid) compared to KPN cells. ↗
▶ Ep 127 · 11:05
clinical Secondary bile acids and deoxycholic acid metabolites are exclusively bacterially produced. ↗
▶ Ep 127 · 11:05
clinical Secondary bile acids and deoxycholic acid metabolites are exclusively bacterially produced. ↗
▶ Ep 127 · 11:05
clinical Preliminary in vitro data shows AKPT cells have more proliferative response to secondary bile acids (like deoxycholic acid) compared to KPN cells. ↗

Summaries Ryan gave as host · 7 summaries

Recaps of other experts' statements, not Ryan's own clinical position.

Summaries Ryan gave as host · Colorectal / ARM & Hirschsprung 7 summaries

Open the Colorectal / ARM & Hirschsprung collection →

Best of the Best Gen Surg - Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence - Dr. Morgan

▶ Ep 127 · 0:45
host summary Ryan Morgan summarizing the discussion: Traditional paradigms suggest recurrences are due to either incomplete resection or occult metastases left behind at the time of surgery. ↗
▶ Ep 127 · 0:58
host summary Ryan Morgan summarizing the discussion: Exfoliated cancer cells in the lumen of the bowel may be a source of recurrence. ↗
▶ Ep 127 · 1:04
host summary Ryan Morgan summarizing the discussion: In the 1980s, UMLB showed that exfoliated cancer cells are present and viable at the time of surgery. ↗
▶ Ep 127 · 1:09
host summary Ryan Morgan summarizing the discussion: Experimental cells could cross a watertight anastomosis in a mouse model. ↗
▶ Ep 127 · 1:14
host summary Ryan Morgan summarizing the discussion: Rectal washout decreases rates of local recurrence after rectal cancer resection. ↗
▶ Ep 127 · 2:15
host summary Ryan Morgan summarizing the discussion: AKPT and KPN organoid cell lines demonstrate a wide range of metastatic potential in animal models. ↗
▶ Ep 127 · 9:23
host summary Ryan Morgan summarizing the discussion: Combined mechanical and antibiotic bowel preparation preoperatively decreases rates of colorectal cancer recurrence. ↗