22 statements
· 2 topics
· summaries given as host listed separately
Featured statements
▶Ep 17 · 7:06
Therefore, antenatal AFV treatment is a promising avenue to restore normal vascular development in hypoplastic lungs and potentially prevent post natal pulmonary hypertension attention in babies with CDH.
Fetal lung vascular remodeling predisposes fetuses with CDH to post natal pulmonary hypertension, which plays a central role in the poor outcomes of these babies.
BOB in Ped Surg 2023 - EUPSA Winner - Dr. Rebeca Figueira
▶Ep 17 · 2:22
clinicalVascular remodeling was attenuated in hypoplastic treated human fetal lungs after AFSEV administration.↗
▶Ep 17 · 2:22
clinicalAngiogenic factors were rescued back to normal levels after AFSEV treatment in human fetal hypoplastic lungs.↗
▶Ep 17 · 2:22
clinicalSingle nucleus RNA sequencing revealed a striking difference between control and CDH in the pattern and distribution of endothelial cells, which was rescued to normal distribution following AFSEV treatment.↗
▶Ep 17 · 2:22
clinical245 differentially expressed genes that regulate vasculogenesis and angiogenesis were down-regulated in CDH lungs and up-regulated in CDH treated lungs.↗
▶Ep 17 · 2:22
clinicalAFSEV cargo contains microRNAs that control processes like angiogenesis and proliferation and migration of vascular endothelial cells.↗
▶Ep 17 · 2:22
clinicalAFSEVs attenuated the severity of right ventricular hypertrophy in CDH hearts.↗
▶Ep 17 · 2:22
clinicalVascular density was restored by AFSEV treatment in human fetal lung explant model of pulmonary hypoplasia.↗
▶Ep 17 · 2:22
quoteFetal lung vascular remodeling predisposes fetuses with CDH to post natal pulmonary hypertension, which plays a central role in the poor outcomes of these babies.↗
▶Ep 17 · 2:22
quoteThere's consensus that the prenatal period offers a window of opportunity to promote normal lung development. However, no antenatal treatments tested to date have been successful.↗
▶Ep 17 · 2:22
quoteWe reported that AFVs promote growth and maturation in fetal hypoplastic lungs. And that these beneficial effects were exerted via the release of RNA cargo.↗
▶Ep 17 · 2:22
clinicalFetal lung vascular remodeling predisposes fetuses with CDH to postnatal pulmonary hypertension, which plays a central role in the poor outcomes of these babies.↗
▶Ep 17 · 2:22
clinicalThe prenatal period offers a window of opportunity to promote normal lung development in CDH.↗
▶Ep 17 · 2:22
clinicalNo antenatal treatments tested to date have been successful in fully rescuing normal lung development in CDH.↗
▶Ep 17 · 2:22
clinicalAFSEVs promote growth and maturation in fetal hypoplastic lungs via the release of RNA cargo.↗
▶Ep 17 · 2:22
clinicalVascular density was rescued back to normal levels after AFSEV administration in rat CDH lungs.↗
▶Ep 17 · 2:22
clinicalVascular remodeling was attenuated in CDH treated lungs after AFSEV administration.↗
▶Ep 17 · 2:22
clinicalAngiogenic factors were rescued back to normal levels after AFSEV treatment in rat CDH lungs.↗
▶Ep 17 · 7:06
quoteTherefore, antenatal AFV treatment is a promising avenue to restore normal vascular development in hypoplastic lungs and potentially prevent post natal pulmonary hypertension attention in babies with CDH.↗
▶Ep 17 · 8:46
clinicalOngoing studies in large animals are being conducted to determine the right dose, route, and whether multiple administrations are needed for AFSEV treatment.↗
▶Ep 17 · 8:46
clinicalAFSEVs themselves are less immunogenic than isolated microRNAs and deliver the whole cargo, not only the microRNAs.↗
▶Ep 17 · 8:46
clinicalAFSEVs administered to the mother intravenously can reach the fetal lungs.↗
BOB in Ped Surg 2023 - EUPSA Winner - Dr. Rebeca Figueira
▶Ep 17 · 8:46
host summaryRebecca Figueira summarizing a resource: A New England Journal of Medicine paper described enzyme replacement therapy administered via umbilical vein multiple times (at least six times every second week).↗
