Our compound of interest is oroonin, a diterpenoid that's derived from the plant species Rhabdosa rubiscens. This plant has been used for hundreds of years in eastern medicine to treat common ailments such as cough, abdominal pain, and muscle aches.
Intestinal fibrosis is a common sequela of IBD. It's found more frequently in Crohn's, affecting 30-50% of those patients, but it is also seen with ulcerative colitis, although less frequently at a rate of 5%.
Best of the Best Gen Surg - Therapeutic Effect of Oridonin against Inflammatory Bowel Disease Involves Inhibition of Intestinal Fibrosis via NF-kB and p38STAT1 Pathways - Dr. Mao
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epidemiologicalInflammatory bowel disease affects approximately 3 million adults in the United States.↗
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epidemiologicalThe value of work-related opportunity lost due to IBD has been reported to be up to $5.5 billion.↗
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epidemiologicalIntestinal fibrosis affects 30-50% of Crohn's disease patients.↗
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epidemiologicalIntestinal fibrosis is seen with ulcerative colitis at a rate of 5%.↗
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clinicalThe fibrosis process can lead to complications that present clinically in the form of strictures, obstruction, and fistulas.↗
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clinicalEpithelial mesenchymal transition (EMT) is defined by the loss of adherences, tight junctions, and cytoskeleton proteins that are normally found in epithelial cells, with loss of epithelial markers such as E-cadherin and ZO-1.↗
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clinicalDuring EMT, cells gain extracellular matrix and fibroblast morphology as well as migratory capacity, with increased expression of fibroblast markers such as α-SMA and fibronectin.↗
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epidemiologicalAnnual medical expenses for a patient with IBD is estimated to be $15,000.↗
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quoteSo inflammatory bowel disease or IBD affects approximately 3 million adults in the United States, and it has significant costs for both patients and society.↗
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quoteIntestinal fibrosis is a common sequela of IBD. It's found more frequently in Crohn's, affecting 30-50% of those patients, but it is also seen with ulcerative colitis, although less frequently at a rate of 5%.↗
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quoteEMT or epithelial mesenchymal transition is a process that contributes to the development of fibrosis.↗
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quoteOur compound of interest is oroonin, a diterpenoid that's derived from the plant species Rhabdosa rubiscens. This plant has been used for hundreds of years in eastern medicine to treat common ailments such as cough, abdominal pain, and muscle aches.↗
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clinicalResearch has demonstrated that oridonin has antioxidant, anti-tumor, and anti-inflammatory effects on various tissues, thought to be due to inhibition of multiple signaling pathways including NF-κB and P38.↗
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clinicalIn studies with in vitro experiments and animal models, oridonin has resulted in slower IBD disease progression and decreased levels of inflammatory cytokines and cells.↗
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clinicalOridonin is a diterpenoid derived from the plant species Rhabdosa rubiscens.↗
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clinicalRhabdosa rubiscens has been used for hundreds of years in eastern medicine to treat common ailments such as cough, abdominal pain, and muscle aches.↗
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quoteWe had two hypotheses with our study. First, we hypothesized that oroonin would attenuate inflammation-related EMT and fibrogenesis, and second, we hypothesized that this would occur through suppression of known pro-inflammatory pathways such as NF kappa B and P38.↗
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clinicalOridonin inhibited LPS-induced increases in fibronectin, another marker of EMT and fibrosis.↗
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clinicalOridonin inhibited LPS-induced increases in α-SMA, a marker of EMT and fibrosis.↗
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clinicalPre-treatment with oridonin attenuated LPS-induced decreases in ZO-1 levels and restored ZO-1 expression.↗
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clinicalNF-κB is a key pro-inflammatory pathway that regulates α-SMA.↗
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clinicalOridonin inhibited the phosphorylation of IKK-α/β and I-κB-α, and prevented total I-κB-α degradation.↗
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clinicalOridonin inhibited the activation of NF-κB by preventing the nuclear translocation of NF-κB p65.↗
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clinicalOridonin inhibits LPS-induced STAT1 activity, which is a downstream factor of P38.↗
clinicalOridonin inhibits EMT-related fibrosis via inhibition of the NF-κB and P38/STAT1 pathways.↗
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quoteIn conclusion, we found that orodonin inhibits EMT-related fibrosis and does so via inhibition of the NF kappa B and P38 1 pathways. Consequently, oroonin may be a promising drug candidate for IBD and specifically within the context of fibrosis.↗
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clinicalAfter breaking down the Rhabdosa rubiscens plant, researchers found that the most active compound was oridonin.↗
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clinicalOridonin is derived from China and used in eastern medicine, having been utilized for hundreds of years for common ailments.↗
