Pancreatitis in pediatric patients with pancreatic solid pseudopapillary neoplasms- a single center experience
Solid pseudopapillary neoplasms are one of the most frequent pancreatic tumors in pediatric patients
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:09 ↗
Surgery for solid pseudopapillary neoplasms is usually curative and outcomes are excellent
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:15 ↗
In a single center study, 10 adolescent girls underwent surgical resection for solid pseudopapillary neoplasms
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:22 ↗
3 out of 10 patients developed acute recurrent or chronic pancreatitis after resection
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:25 ↗
Every patient who developed ongoing pancreatitis had genetic risk factors like CFTR gene variants or pancreas divisum
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:32 ↗
Some patients with post-resection pancreatitis ultimately required completion pancreatectomy
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:40 ↗
Identifying genetic and anatomic risk factors before surgery may change management of patients with solid pseudopapillary neoplasms
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:48 ↗
Function Tests & Pain Management: Pancreatic Disease
Direct pancreatic function testing means obtaining function directly from the pancreas, not relying on stool testing for fecal elastase.
clinical0:05 ↗
Endoscopic pancreatic function testing replaced the duodenal-tube (drilling) method by the end of the 1990s/early 2000s.
clinical2:07 ↗
Dr. Conwell and colleagues at Tyler Stevens launched endoscopic function testing, showing comparable results to duodenal-tube testing for bicarbonate and lipase measurement.
clinical2:13 ↗
Endoscopic collection became the standard because duodenal-tube testing requires the patient to be awake, placement of two tubes, and interventional radiology.
clinical2:39 ↗
The Cincinnati protocol uses secretin 0.2 mcg/kg or CCK 0.04 mcg/kg at time zero, then collects duodenal aspirates every 5 minutes for three samples using an ERCP tapered catheter.
clinical3:05 ↗
The lab at Cincinnati Children's Hospital measures activities for four enzymes: trypsin, amylase, lipase, and chemotrypsin.
clinical3:46 ↗
Pancreatic function can be abnormal if checked around an acute attack.
clinical4:25 ↗
Exocrine pancreatic maturation occurs over the first 2 to 3 years of life.
clinical4:33 ↗
MR pancreatic function testing acquires identical imaging pre- and post-secretin to quantify the volume of fluid secreted into the gastrointestinal tract.
clinicalAndrew Trout5:18 ↗
The delay between pre- and post-secretin MR imaging is about 15 minutes to allow fluid accumulation.
clinicalAndrew Trout6:27 ↗
MR-PFT can threshold images and quantify secreted fluid volume by subtracting pre-secretin from post-secretin fluid volume.
clinicalAndrew Trout7:38 ↗
Phantom studies have proven that MR can accurately quantitate fluid volume.
clinicalAndrew Trout8:13 ↗
Preliminary data in about 35 patients are examining correlation between MR-PFT and endoscopic pancreatic function testing.
clinicalAndrew Trout8:28 ↗
Qualitative MR exocrine assessment appears different between pediatric and adult patients, suggesting possible size or weight dependency.
opinionAndrew Trout8:49 ↗
In chronic or acute recurrent pancreatitis patients with ductal changes, the pancreatic duct is often dilated and abnormal at baseline, so secretin may not be needed to visualize the duct.
opinionAndrew Trout9:41 ↗
Low-fat diet, pancreatic enzyme replacement therapy (PERT), antioxidants, and steroids have never been shown to prevent recurrent pancreatitis episodes or pancreatic pain episodes.
clinical12:05 ↗
The case patient was PRSS1-positive on genetic testing.
clinical12:43 ↗
The case patient had low fecal elastase on two occasions and endoscopic PFTs showed low amylase and lipase, borderline low trypsin and chemotrypsin.
clinical12:47 ↗
The case patient had normal hemoglobin A1C and normal mixed meal test for endocrine function.
clinical13:01 ↗
The case patient showed evidence of ductal changes on ERCP, confirming chronic pancreatitis based on imaging and ERCP findings.
clinical13:09 ↗
The case patient has been pain-free on PERT treatment for several months with catch-up growth.
clinical13:17 ↗
The multidisciplinary pain consult at Cincinnati comprises three disciplines: pain physician (medical/psychosocial assessment, medication, interventional management), psychologist (100% of the time, not optional), and nurses.
clinicalGoldschneider15:00 ↗
Cognitive-behavioral therapy is the standard, state-of-the-art therapy for pain management.
guidelineGoldschneider18:16 ↗