The role of preoperative imaging and tumor markers in predicting malignant ovarian masses in children
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In brief
In brief
This retrospective study of 139 pediatric patients (2010-2015) identified key predictors of malignant ovarian masses: tumor diameter ≥10cm, solid/complex imaging characteristics, and abnormal tumor markers. These preoperative factors guide surgical approach—radical resection for high-risk features versus ovarian-sparing surgery for low-risk cases.
Written by the GCMD Library team from the article.
Abstract
Purpose
To investigate the clinicopathololgic characteristics and the predicting value of preoperative imaging and tumor markers in children with ovarian masses.
Methods
Patients admitted in Shanghai children’s hospital with ovary neoplasms between 2010.01 and 2015.12 were retrospectively analyzed. The medical records including age at operation, presentation of symptoms and signs, tumor marker, imaging, pathology, tumor diameter and surgical choice were reviewed. All data were analyzed using SPSS 17.0
Results
A total of 139 patients were included, among which 116 were benign neoplasms and 23 malignant tumors. There was significance difference relation with the tumor diameter, character, torsion and tumor markers, but not the age, position, calculi, and symptoms. The risk factors include tumor diameters ≥ 10 cm, the odds ratio (OR) was 11, 95% confidence interval (CI) was 3–36, solid/complex tumor (OR 6, 95% CI 2, 14) and positive in tumor markers (OR 84, 95% CI 20, 345). Among the patients with benign neoplasms, 77 of them had laparoscopic ovarian cystectomy while 23 patients with malignant tumors had salpingo-oophorectomy and omentum resection.
Conclusion
Preoperative imaging and tumor markers could help identifying the malignant ovarian masses in children. If tumor diameter ≥ 10 cm, solid/complex in imaging and tumor markers abnormal, a radical resection is mandatory; otherwise, an ovarian-sparing surgery is recommended.