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The artificial womb: What is the next step?
jpedsurg.org shows its articles on its own site.
Read the article on jpedsurg.org ↗Article · Jan 2019 · 1 min read
In brief
In brief
Commentary on groundbreaking artificial womb technology for premature neonates, highlighting the critical challenge of heparin dependence in current devices. Proposes vascular endothelial cell coating as a potential solution to reduce thrombogenicity and anticoagulation requirements in extracorporeal support systems.
Written by the GCMD Library team from the article.
Recently the journal published the bold groundbreaking work of Joseph Church (et al.) [1,2]. It represents a major step forward in the care of premature neonates. However, as he noted, the utility of the technique will be severely limited as long as the devices require high dose heparin. While he hopes to create cannulas and an oxygenator without thrombogenic surfaces, this seems unlikely to succeed unless he is able to clone vascular endothelial cells. In that case, the cells suspended in their culture medium could be instilled into the devices and allowed to coat their surfaces.
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