Multicenter pre-operative assessment of pediatric ovarian malignancy
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Read the article on jpedsurg.org ↗Article · Mar 2019 · 1 min read
In brief
In brief
Multicenter study develops preoperative risk stratification for pediatric ovarian masses based on imaging characteristics and tumor markers. Simple cysts and marker-negative heterogeneous lesions ≤10cm show low malignancy risk (0-5%), supporting ovarian-sparing resection, while solid masses and marker-elevated lesions warrant oophorectomy.
Written by the GCMD Library team from the article.
Purpose
The purpose of this study was to develop a pre-operative risk assessment tool for childhood and adolescent ovarian malignancy, in order to guide operative management of pediatric ovarian masses.
Methods
We conducted a retrospective analysis of patients 10 cm) marker-negative heterogeneous lesions had malignancy proportions of 0% (0/39, 95% CI = 0–11%) and 5% (2/40, 95% CI = 1–18%), respectively.
Conclusions
Given the malignancy estimates identified from these multi-institutional data, we recommend an attempt at ovarian-sparing resection for simple cysts or tumor marker-negative heterogeneous lesions ≤10 cm. Oophorectomy is recommended for solid masses or heterogeneous lesions with elevated markers. Finally, large (>10 cm) heterogeneous masses with non-elevated markers warrant a careful discussion of ovarian-sparing techniques. Complete surgical staging is mandatory regardless of operative procedure.
Type of Study
Study of Diagnostic Test.
Level of Evidence
Level I.