Impact of extent of resection on survival in high-risk neuroblastoma: A systematic review and meta-analysis
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In brief
In brief
Systematic review and meta-analysis of 19 studies (2358 patients) examining whether extent of surgical resection impacts survival in high-risk neuroblastoma. Findings show gross total resection significantly reduces 3-year mortality compared to subtotal resection, informing surgical decision-making in this challenging pediatric malignancy.
Written by the GCMD Library team from the article.
Background
Despite the development of new treatment options, the prognosis of high-risk neuroblastoma patients is still poor. Many studies designed to elaborate the association between the extent of resection (EOR) and outcome have reported conflicting results. We performed a meta-analysis to assess whether greater EOR is associated with improved overall survival (OS) and event-free survival (EFS) in patients with high-risk neuroblastoma.
Methods
Embase, PubMed, Cochrane library, and conference proceedings were searched between March 10 and October 1, 2017. Studies of pediatric patients with newly diagnosed high-risk neuroblastoma comparing various EOR and presenting objective overall or event-free survival data were included. Primary outcomes were relative risk (RR) for mortality at 3 and 5 years. Secondary outcomes were 3-year and 5-year EFS rates.
Results
19 retrospective studies including a total of 2358 cases were identified. Compared with subtotal resection (STR), patients who underwent gross total resection (GTR) had significantly decreased mortality at 3 years (RR, 0.69; 95% CI, 0.58–0.82; P